Despite decreasing dementia rates among people with HIV, this patient population remains more likely to have dementia than those without HIV, according to results published in AIDS. Jennifer Lam, PhD, MPH, and colleagues compared dementia incidence after age 50 by HIV status among 13,296 people with and 155,354 people without HIV. At baseline, mean age was 54 for both groups and 80% of people with HIV had less than 200 HIV RNA copies/mL. During 2000-2016, overall dementia incidence was higher among people with HIV (adjusted incidence rate ratio [aIRR], 1.80; 95% CI, 1.60-2.04). Dementia incidence declined among both people with and without HIV (−8.0 and −3.1% per period, respectively), but continued to be higher among people with HIV in 2015-2016 (aIRR, 1.58; 95% CI, 1.18-2.12). From 2000-2016, dementia prevalence was higher overall among people with HIV (adjusted prevalence ratio [aPR], 1.86; 95% CI, 1.70-2.04) and was higher among people with HIV in 2015-2016 (aPR, 1.75; 95% CI, 1.56-1.97).