Current pneumococcal immunizations cover the 10 to 23 most normal serotypes of the 92 as of now portrayed. Notwithstanding, with the expanded use of pneumococcal-serotype-based immunizations, the danger of serotype substitution and an expansion in infection brought about by nonvaccine serotypes remains. Serotype reconnaissance of pneumococcal contaminations depends vigorously on culture strategies, which are known to be heartless, especially in instances of noninvasive illness. Pneumococcal-serotype-explicit pee tests offer an elective strategy for serotyping for both obtrusive and noninvasive sickness. Nonetheless, the measures portrayed already cover chiefly form immunization serotypes, give little data about flowing non vaccine serotypes, and are presently accessible just in a couple of expert research facilities. Our research facility has built up a Luminex-based stretched out reach antigen catch examine to recognize pneumococcal-serotype-explicit antigens in pee tests. The test targets 24 particular serotypes/serogroups in addition to the cell divider polysaccharide (CWP) and some cross-responsive serotypes. We report that the measure is equipped for distinguishing all the focused on serotypes and the CWP at 0.1 ng/ml, while some serotypes are recognized at fixations as low as 0.3 pg/ml.
Reference link- https://cvi.asm.org/content/24/12/e00262-17