Fas’ roles in the immune system are multifaceted, and the interaction between Fas receptor and Fas ligand is essential for maintaining immune tolerance. We aimed to assess the expression of Fas receptor on nasal inferior turbinate mucosa in patients with M PAR and M/S PAR. We determined the relationship between disease severity and the production of Fas.
A total of 70 patients with M/S PAR, 70 patients with M PAR, and 70 healthy individuals were enrolled in this study. We obtained biopsies of nasal inferior turbinate mucosa from the participants. A real-time polymerase chain reaction evaluated the expression of Fas mRNA. The presence and location of Fas were determined by immunohistochemistry. Researchers measured the number of eosinophils per field, blood eosinophils, total serum IgE levels, and specific serum IgE levels. TNSS assessed the clinical manifestations of patients.
Fas’ expression in patients with M/S PAR was decreased significantly compared to the control group and patients with M PAR. Local mucosal expression of Fas was correlated with specific IgE, nasal eosinophil count, and TNSS.
The study concluded that there might be a relationship between the expression of Fas receptor on nasal turbinate mucosa and the severity of persistent allergic rhinitis.
Reference: https://journals.sagepub.com/doi/full/10.1177/1945892418824246
