The mechanism of lncRNAs involved in developing AR remains unclear. The researchers evaluated the mechanism by which differentially expressed lncRNAs contribute to the pathogenesis of AR.
Expression profiles of lncRNAs and mRNAs were analyzed by microarray detection from the blood samples of 3 AR patients and three control subjects. The main lncRNAs were verified by qRT-PCR in 16 AR patients’ peripheral blood and 18 control subjects. GO, Pathway, and Disease analysis of differentially expressed lncRNAs and mRNAs, and transcription factor prediction analysis were performed to explore the synergistic effect of differentially expressed lncRNAs function-related mRNAs on AR pathogenesis.
Thirty-one lncRNAs were differentially expressed in the peripheral blood from AR patients, and 4 of the five most differentially expressed lncRNAs had significantly higher levels in AR patients than in control subjects’ qRT-PCR analysis. GO, Pathway, and Disease analyses indicated that the four lncRNAs were correlated with seven mRNAs enriched in inflammation, immune response, and allergic diseases.
The study concluded that it provides new insights into how lncRNAs and their function-related mRNAs might contribute to AR.
Reference: https://journals.sagepub.com/doi/full/10.1177/1945892420912164
