Reductions in muscle indicators such as creatine phosphokinase (CK) in rheumatic illnesses, as well as their relationship with decreased muscle mass, maybe clinically significant in osteoarthritis (OA). Given the complexities of secondary sarcopenia, it is critical to define the relationship between muscle indicators and sarcopenia as well as to disentangle the participation of OA-related diseases. Researchers looked studied the relationship between serum muscle biomarkers and sarcopenia in individuals with OA, taking into account the existence of pain and inflammation. A single-center cross-sectional study from the Screening for People Suffering Sarcopenia in Orthopedic Cohort of Kobe research comprised 1425 patients with knee and hip OA scheduled for joint replacement surgery. The primary result was sarcopenia, which was determined by two criteria. The numeric rating scale and serum C-reactive protein (CRP) levels were used to assess pain and inflammation, respectively. Logistic regression models were used to investigate the relationships between the biomarkers and sarcopenia. Sarcopenia was diagnosed in 4.0 percent of patients using the Asian Working Group for Sarcopenia criteria. Sarcopenia was related with higher serum CK levels but not with serum aspartate aminotransferase or alanine aminotransferase levels in adjusted analyses, regardless of pain score or serum CRP. Sarcopenia was not related to either the pain score or the serum CRP level. When the European Working Group on Sarcopenia in Older People criteria were applied, similar findings were obtained.

Serum CK was linked to sarcopenia, indicating that it may be used to diagnose sarcopenia in OA regardless of pain or inflammation.

Reference:https://journals.lww.com/jclinrheum/Abstract/2021/03000/Disentangling_Associations_Between_Serum_Muscle.4.aspx