For a study, researchers sought to examine the neuroanatomy and physiology of basal and reflex tearing and to describe current and future treatments for dry eye disease (DED) that use the idea of neurostimulation.

The majority of current DED therapies aim to either lessen inflammation or augment low tear volume and tear components. By stimulating the neurons that produce the different tear components, neurostimulation was a novel strategy that has gained popularity in recent years. It aims to increase the production of all basal tear components. Through two arms of the sensory trigeminal nerves, the neuroanatomy of the lacrimal unit offers a number of potential entry sites to induce the production of tears. Chemical or energy in the form of electrical or magnetic energy is two stimulation methods. Lacrimal, goblet cell and meibomian gland activation with neurostimulation have all been demonstrated in research to date. Symptoms of DED are supposedly improved. Clinical studies have shown that neurostimulation reduces the DED symptoms and indicators by boosting basal tear volume and production.

It was shown that neurostimulation utilizing electrical, mechanical, or chemical methods was an efficient, safe, and well-tolerated way of controlling DED. The goal of the unique concept is to boost tear production.

Reference: journals.lww.com/co-allergy/Abstract/2022/10000/Neurostimulation_for_dry_eye_disease.9.aspx