This study focuses on Rapid global dissemination of carbapenemase-producing Enterobacteriaceae (CPE) poses a public health threat (1). To prevent the spread of CPE in healthcare settings, international guidelines advocate for early identification, isolation, and contact precautions (2,3). To provide information helpful for the design of rational infection control policies, we estimated CPE carriage duration in a hospital cohort and identified risk factors for prolonged carriage.

During October 2016–February 2018, we conducted a prospective cohort study involving CPE carriers from 2 tertiary care centers in Singapore. CPE carriers were identified by routine collection of rectal swab samples in accordance with local infection control policies. We included patients who were >21 years of age and had the capacity to provide consent. We retrieved from medical records of enrolled patients the latest dates of CPE-negative rectal swab samples before the first positive sample. We collected fecal samples from participants at the time of enrollment, weekly for 4 weeks, monthly for 5 months, and bimonthly for 6 months. We recorded demographic characteristics, healthcare contact history, and medication history.The fecal samples were inoculated onto selective chromogenic.

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