THURSDAY, Dec. 5, 2019 (HealthDay News) — Current and former electronic cigarette users have increased odds of depression compared with never users, according to a study published online Dec. 4 in JAMA Network Open.

Olufunmilayo H. Obisesan, M.D., M.P.H., from the American Heart Association Tobacco Regulation and Addiction Center in Dallas, and colleagues examined the correlation between e-cigarette use and depression using data from the Behavioral Risk Factor Surveillance System database in 2016 to 2017. Data were included for 892,394 participants.

Using multivariable adjusted models, the researchers found that compared with never users, former e-cigarette users had 1.60-fold increased odds of reporting a history of clinical diagnosis of depression, while current e-cigarette users had 2.10-fold higher odds. Compared with never users, among current e-cigarette users, the odds of reporting depression were higher with increased frequency of use (daily use: odds ratio, 2.39; occasional use: odds ratio, 1.96). In subgroup analyses by sex, race/ethnicity, smoking status, and student status, the results were similar.

“Our results suggest a strong association between e-cigarette use and depression, and this may have potential implications for regulation of e-cigarettes,” the authors write. “Our results also highlighted the need for longitudinal studies to investigate the risk of depression associated with e-cigarette use and the potential bidirectionality of the association between e-cigarette use and depression.”

Several authors disclosed financial ties to the pharmaceutical industry.

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