The prognosis of early gastric cancer (EGC) is better than invasive gastric carcinoma, with a 5-year survival rate of more than 905 after surgery. However, the involvement of lymph nodes and lymphatic vessels in EGC prognosis is unclear. The objective of this study is to evaluate the involvement of lymphatic nodes and vessels in early gastric cancer.

This is a clinical, multicenter study conducted across 23 centers in France. The study included the clinical, pathological, and therapeutic data of 332 patients with EGC who underwent surgery. The primary outcome of the study was the cumulative 5-year and 7-year specific survival rates of EGC without any lymphatic involvement.

The 5-year and 7-year survival rates of the participants with ECG were 92% and 87.5%, respectively.  34 (10.2%) patients had lymphatic spread; 13 were close to the tumor, 17 in one lymph node, and 4 in both nodes and lymphatic vessels. Lymph node involvement was positively associated with submucosal invasion and lymphatic vessel involvement. The researchers found prognosis to be the poorest in patients with lymphatic involvement.

The research concluded that lymphatic involvement was a crucial prognostic factor in patients with early gastric cancer. Patients with lymphatic involvement are at a higher risk of poorer prognosis of EGC.