Nephrolithiasis is expensive for everyone, from healthcare systems to individuals. For this study, researchers aimed to assess the financial burden of disease associated with nephrolithiasis, with a focus on treatment method economic efficiency. Disposable flexible ureteroscopes appear to promote economic efficiency in lower volume practices and circumstances where there was a high chance of scope damage. The rise in the global prevalence of stone disease was a significant contributor to the rising expenditures connected with nephrolithiasis. The majority of the expenditures associated with kidney stones were attributed to ER visits and inpatient treatment. In situations when such a move is possible, there were chances to save money by moving care to outpatient settings. Inappropriately selected patient populations, metaphylaxis, and preventative methods were successful at lowering costs. The most cost-effective ways of surgically treating stone disease are flexible ureteroscopy and percutaneous nephrolithotomy (PCNL), with PCNL reserved for big and lower pole stones. While time away from work and other indirect expenses were difficult to estimate, they were essential concerns in the economics of nephrolithiasis.