Dexmedetomidine and remifentanil are expected to blunt the acute hemodynamic responses after intranasal injection of epinephrine. This study was done to check the difference in the 2 drugs in their abilities to blunt the hemodynamic responses in the intraoperative period and postoperative profile.

The patients were randomly divided into the dexmedetomidine and remifentanil groups. The hemodynamic values were recorded. The surgical condition was also assessed.

No significant differences in hemodynamic variables were found between the groups before and after the intranasal injection of epinephrine. Blood pressure values in the remifentanil group were significantly lower than those in the dexmedetomidine group. The sedation score was significantly lower in the dexmedetomidine group on arrival and at 30 minutes after arrival at the postanesthetic care unit. At 30 and 60 minutes after the operation, the pain scores were significantly lower in the dexmedetomidine group.

The study concluded through its findings that the Dexmedetomidine had better postoperative sedative and analgesic effects than remifentanil for patients undergoing endoscopic sinus surgery in this study. Remifentanil was superior to dexmedetomidine in inducing hypotension during endotracheal intubation.