CSM or cervical spondylotic Myelopathy is known as one of the major causes of spinal cord dysfunction which results in an unpredictable prognosis. In this process, the CSF or cerebrospinal fluid biomarker levels are being alternated with CSM tu to relate the neurological status and its outcome. The changes in the spinal cord are being evaluated through MRI.  The study included patients of CSM with an average age of 67.7 years. The researchers have found that in the CSM subjects the subunit of neurofilament light and fibrillary acidic protein concentrations became higher. Along with that, the concentrations of fatty acid-binding protein  3, amyloid-beta, and peptide became lower. These kinds of patients started improving at a higher rate. This study started prior to the surgery and continued 3 months after that.

As a result of that, it can be said that CSF biomarkers of axonal and glial damage synaptic changes, and inflammation can be altered in CSM patients. This can be reflected in CSM pathophysiology and become an aid for prognostication. This study has created data for a postoperative biomarker that can be used during the follow-up time to validate the cases in the long run.

Ref: https://thejns.org/spine/view/journals/j-neurosurg-spine/aop/article-10.3171-2020.8.SPINE20965/article-10.3171-2020.8.SPINE20965.xml