Although anthropometric and hormone-related variables are well-established endometrial cancer risk factors, little is known regarding their influence on endometrial cancer risk in non-White women.
In the Multiethnic Cohort (MEC) Study, 1150 invasive endometrial malignancies were detected among 110,712 women. The researchers estimated the risk ratios (HRs) and 95% confidence intervals (CIs) for race/ethnicity and risk variables across racial/ethnic groups for relationships with endometrial cancer risk.
A greater BMI at baseline or age 21 years was highly related to an increased risk (pint race/ethnicity ≥ 0.36). Except for African Americans, parity (vs nulliparity) was inversely related to risk in all groups (pint 0.006). In Whites and Japanese Americans, current use of postmenopausal hormones (PMH-E; versus never use) was related to an elevated risk (pint 0.002). Endometrial cancer risk was reduced in Japanese Americans and Latinas compared to Whites, but non-significantly greater in Native Hawaiians. The risk for African Americans was the same as it was for Whites.