For a study, researchers sought to provide an overview of the research on numerous promising minimally invasive tests for eosinophilic esophagitis (EoE).  Using PubMed, literature searches were carried out. Eosinophilic esophagitis and minimally invasive procedures, such as the esophageal string test, Cytosponge, transnasal endoscopy, technetium-labeled heparin, and noninvasive biomarkers, were also used as keyword combinations. Peer-reviewed reviews, systematic reviews, and retrospective and prospective observational studies were chosen. Data were examined and compiled. In past years, several methods have been created to assess EoE disease activity without traditional endoscopy. The study provided a summary of these methods, their advantages and disadvantages, and the potential prospects for their use in clinical practice and academic research. The development of minimally invasive methods to assess EoE disease activity has advanced tremendously. Each method discussed in this review had benefits and drawbacks; some were more likely to be adopted widely than others.

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