In this current study We constructed an in vitro vascular model with 1.25-in. flexible vinyl tubing connected in a loop to a pulse-generating pump (Series 1400; Harvard Apparatus, Holliston, Mass) simulating intra-arterial conditions. Cook Zenith Alpha stent grafts (Cook Medical, Bloomington, Ind), Gore DrySeal sheaths (W.L. Gore and Assoc, Newark, Del), and Medtronic Sentrant Introducer (Medtronic, Dublin, Ireland) sheaths were tested. Each sheath was inserted to a length equating to a preset surface area. The circuit was flushed with 1 L of buffered Ringer’s fluid (RL) for 30 minutes before each sheath run. After sheath insertion, a fresh 1 L of RL was used to run the circuit for 150 minutes at a simulated cardiac output of 3 L/min. A flush wash with RL was subsequently collected. Six sheaths from each manufacturer were tested, and three noncoated Cook Check-Flo Performer Introducer sheaths (Cook Medical) were tested as controls. The fluid samples were quantified using vacuum filtration, drying, and weighing. The composition of the products was qualified using infrared spectroscopy and attenuated total reflectance.

Hence we conclude Attenuated total reflectance analysis revealed that the composition of hydrophilic polymer residue from the coated sheaths identical to the characteristic wavenumber of 1600 to 1700/cm.

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