Multiple combinations of inherited and acquired risk factors are related to thrombotic events in adult patients with inflammatory bowel disease (IBD). For a study, researchers sought to determine whether thromboembolic risk factors were also present in children with IBD. Investigators enrolled 3 groups of children: 1 with Crohn’s disease (cD), 1 with ulcerative colitis (Uc), and a healthy control group. The prospective thromboembolic risk of each participant was assessed clinically and with laboratory tests. About 30 children (25.6%) with CD, 28 children (23.9%) with UC, and 59 healthy control kids (50.4%) were examined. Based on the Pediatric Crohn Disease Activity Index, there were no significant differences between thromboembolic risk variables and disease activity. In contrast, the Pediatric Ulcerative Colitis Activity Index revealed a statistically significant difference in blood fibrinogen levels between patients with mild and moderate/severe illness [3.8 (3.2–4.5) g/L vs. 5.7 (4.8–6.2) g/L, P<0.0032] Healthy controls had lower homocysteine levels than CD (P=0.176) and UC (P=0.026). An elevated amount of homocysteine was also detected in UC with a homozygous mutation in the methylenetetrahydrofolate reductase C677T gene. Like adults, children with IBD had clinical characteristics and acquired and congenital variables that could raise their thrombotic risk.

Source:journals.lww.com/jpgn/Abstract/2022/05000/Evaluation_of_Risk_for_Thromboembolic_Events_in.10.aspx