The purpose of this study was to determine the level of inflammatory cytokines, eosinophil cationic protein, and IgE in AR patients.

88 AR patients and 88 healthy controls provided the sample of their blood for the purpose of testing. Each of the provided blood samples was analyzed for eosinophil counts by flow cytometry, IgE by ECLIA, ECP, IL-17, and IL-33 by using the ELISA test.

No significant difference between AR patients and the control group in age and gender was observed. Levels of eosinophils, IgE, ECP, IL-17, IL-33, and the total symptom scores were significantly higher in AR patients than the HC. Serum ECP correlated with IL-17, IL-33, and IgE levels in the R patients. There was no correlation between IL-17 and IL-33. There was a correlation between symptom scores and eosinophils, and IgE in the patients. No correlation was observed between symptom scores and ECP, IL-17, and IL-33 in the AR patient

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The study concluded through its findings that the patients with AR have significantly higher serum levels of ECP, IL-17, and IL-33 than healthy controls. This indicates that these markers could be used in order to diagnose AR and to monitor the disease. Inhibitory molecules to IL-17 and IL-33 may be considered as novel treatment strategies.

Reference: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-020-00117-6