Patients who have food allergies run the danger of unintentionally displaying allergy symptoms in daily life. Low thresholds may increase the likelihood of unintentional allergic responses. In order to control food allergies, it is necessary to evaluate the threshold. For a study, researchers offered a management strategy that takes patient age and the severity of food allergies into account while determining the threshold dosage and consumable dose.

Accidental allergic responses are more likely to occur in children who are younger, and school-aged children are more likely to have worse quality of life (QOL) than younger children. Patients with low thresholds could also find it challenging to develop tolerance. In order to assess the threshold and edible dosages for patients with food allergies, they conducted a stepwise oral food challenge (OFC). In the first phase, a low-dose OFC might be used to determine the dose that could be ingested at home without risk, avoiding the need to completely exclude sensitive foods. The danger of unintentional intake might be effectively managed by determining the threshold dosage. Low-dose oral immunotherapy (OIT) would be expected to prevent allergic responses from occurring via inadvertent intake and allow patients who react to low-dose OFC to safely take medium dosages.

Finding the appropriate dosage would make managing the diet and relieving anxiety for those with food allergies and the people who care for them easier. Low-dose OIT and OFC were efficient and well tolerated, which would raise their quality of life. Finding a safe threshold that causes no symptoms while taking into account age and the severity of the food allergy would satisfy the unmet requirements of patients with food allergies.

Reference: journals.lww.com/co-allergy/Abstract/2022/06000/Personalized_management_for_unmet_needs_with_food.3.aspx