Pheochromocytoma and paraganglioma (PPGLs) are neuroendocrine tumours that appear in a variety of ways. PPGLs can be sporadic, but they are frequently linked with a variety of syndromes, each with its own set of clinical symptoms. For staging, therapy, and follow-up, a comprehensive workup is consequently essential. Imaging is a critical component of the PPGL workup and diagnosis. Cross-sectional imaging using radionuclides has improved in terms of specificity and sensitivity for detecting and treating PPGLs. Furthermore, the availability of a wide range of targets on PPGLs has enabled excellent imaging with radionuclides for staging and therapy. Radionuclides are now being studied for use in the staging and therapy of PPGLs.

The development of new radionuclides capable of identifying disease locations and concurrently targeting them has the potential to improve survival and outcomes in patients with PPGLs. Given the clinical variety of PPGLs, increasing the therapeutic arsenal against locally progressed or metastatic PPGLs can enable physicians to properly evaluate and treat PPGLs.