“Is sexual dimorphism true in other allergy disorders as mentioned in anaphylaxis too?”Finding possible answers to this question is the purpose of the study. Potential gender disparities are examined in epidemiology, causes, severity, anaphylactic results and disease pathophysiology. Hormonal state and X-chromosome-coded variables that are profoundly involved in the regulation of T-cell and B-cell responses may influence the gender difference seen in allergy illnesses including asthma and rhinitis. Little is known about whether sex plays a role in anaphylaxis, though the description of catamenial anaphylaxis is intriguing. However, epidemiologic bias, a lack of good animal models for human disease, discrepancies in diagnostic codes, and a lack of harmonised clinical grading are all obstacles to obtaining useful information on this topic.

The female sex predisposes to immunological dysregulation, as seen by the greater incidence of autoimmunity and atopy. Pathomechanisms in anaphylaxis are not entirely understood, triggers are many, and IgE-dependent mast cell degranulation is only a small part of the narrative. Improvements to the disease definition, such as a more accurate coding system and greater investigations into triggers, appear to be the only option to allow a more precise assessment of the possible different risk for women to develop anaphylaxis.

Reference: https://journals.lww.com/co-allergy/Abstract/2019/10000/Gender_differences_in_anaphylaxis.3.aspx