Researchers conducted this study to study gender differences in another cohort of adult patients with CRS who underwent ESS and compared critical histopathologic and serologic features.
Patients with CRS who underwent ESS with structured histopathology reports on surgical samples were studied. The 13-item structured histopathology report detailed key metrics of inflammation and the presence of fungal elements.
We studied 130 eligible subjects. Compared with the men, the women had significantly higher preoperative SNOT-22 scores but similar CT scores. Serum IgE levels were significantly higher among women versus men. Tissue fungal elements were substantially more prevalent in women versus men. Up to this point, the analysis was agnostic of clinical details of the subjects. Women versus men had a higher prevalence of migraine or any primary headache disorders.
The study concluded that women who underwent ESS for CRS had a higher SNOT-22 symptom burden. Worsened symptomatology may be secondary to a higher prevalence of primary headache disorders in women. However, surgeons should also be aware that female patients with CRS who seek ESS may have a higher prevalence of severe disease endotypes and phenotypes.
Reference: https://journals.sagepub.com/doi/full/10.2500/ajra.2017.31.4471
