The etiology of cardiovascular disease (CVD) is significantly influenced by hyperlipidemia. Most hyperlipidemias are treated with statins since they are widely regarded as the most effective class of medications for managing hyperlipidemia. Statin therapy has revolutionized hyperlipidemia management but can negatively affect muscle, the nervous system, and metabolism. The purpose of this research was to determine if there is a dose-response relationship between statin therapy side effects and the age of the study population. Around 200 patients using statins (atorvastatin and rosuvastatin) to treat hyperlipidemias participated in the trial. Different doses of atorvastatin and rosuvastatin were categorized into 4 groups. A total of 6 months were spent keeping tabs on all of the study’s participants. Side effects from statin treatment were recorded and studied. After starting statin treatment, all patients had unwanted side effects. Many people said they experienced negative side effects, and headaches and muscle pain were 2 of the most prevalent. However, there were no severe adverse effects (SAE). None of the reported side effects were serious enough to warrant stopping statin treatment. The study’s findings show that every statin therapy patient will suffer some side effects. The adverse effects were shown to be milder among the elderly.

Source: journals.lww.com/jfmpc/Fulltext/2022/07000/Plethora_of_adverse_drug_reactions_in_geriatric.53.aspx