For a study, regardless of the JIA phenotype, researchers sought to give care guidelines for juvenile idiopathic arthritis (JIA), focusing on nonpharmacologic therapy, medication monitoring, vaccinations, and imaging. Researchers created patient/population, intervention, comparison, and clinically relevant outcome questions. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to grade the quality of evidence after performing a systematic literature review (high, moderate, low, or very low). A voting panel comprised of clinicians and patients/caregivers agreed on the recommendations’ direction (for or against) and strength (strong or conditional). The utilization of physical therapy and occupational therapy therapies and a healthy, well-balanced, age-appropriate diet, specific laboratory monitoring for medications, widespread immunizations, and collaborative decision-making with patients/caregivers were all recommended in the guideline. Nonpharmacologic therapy, medication monitoring, vaccinations, and imaging were all addressed in the disease care of all JIA patients. All of the evidence for the recommendations was rated as poor or very poor quality. As a result, more than half of the recommendations have a condition attached to them. The 2019 American College of Rheumatology JIA and uveitis guidelines targeted polyarthritis, sacroiliitis, enthesitis, and uveitis, and a concurrent 2021 policy on oligoarthritis and temporomandibular arthritis, and systemic JIA, complement the clinical practice guideline. It was intended to assist clinicians, patients, and caregivers in making decisions. The guidelines take into account the severity of both articular and nonarticular symptoms and the patient’s overall quality of life. Although the evidence was generally of poor quality, and many of the recommendations were conditional, the guideline’s relevance and applicability were enhanced by including caregivers and patients in the decision-making process. It was vital to keep in mind that these were only suggestions. The treating doctor and the patient/caregiver should have made clinical decisions, as they should always.