Malignant left ventricular hypertrophy (LVH) refers to a condition when the heart’s left pumping chamber has thickened and may not pump blood efficiently. This study aims to investigate the risk of heart failure (HF) in patients with malignant LVH and myocardial injury.

This community-based, prospective, cohort study included a total of 3,987 African-American participants with the presence or absence of LVH and subclinical myocardial injury. The prevalence of heart failure in this population was studied. The primary outcome of the study was an adjusted association between LVH, subclinical myocardial injury, and the risk of incident HF hospitalization.

During a median follow-up of 9.8 years, a total of 285 incident HF events were reported. Adjusted analyses suggested that higher LV mass and subclinical myocardial injury had independent linear associations with the risk of HF. The highest risk of HF was reported in patients with both LVH and myocardial injury (absolute incidence 35%, aHR 5.35). The findings also suggested that men with LVH and myocardial injury were at a 15-fold higher risk of HF than those with no LVH or myocardial injuries, compared to the 4-fold risk in women.

The research concluded that African-American patients with LVH and myocardial injury were at a significantly higher risk of HF.