The purpose of this study was to correlate thromboelastography (TEG) parameters with biomarkers of hemostasis, bleeding, and transfusions in children and adults with cirrhosis, and to evaluate differences in laboratory tests, bleeding, transfusions, and thrombosis between (1) children without and with cirrhosis and (2) children and adults with cirrhosis. Around 20 healthy children, 40 children with cirrhosis, and 40 adults with cirrhosis who had liver transplants (LT) were included in this single-center retrospective analysis. Demographic information, preoperative laboratory results, and intraoperative TEG measurements were also gathered. The international normalized ratio (INR), platelet count, fibrinogen concentration, clotting time (CT), thrombolysis time (TT), thrombolysis time (CTT), thrombolysis time (TT), thrombolysis time (TTT), alpha angle (α), and maximal amplitude (MA) were all measured. Researchers recorded information about complications like bleeding, transfusion needs, and thrombosis as well. When comparing children with and without cirrhosis, those with cirrhosis had significantly higher rates of aberrant PT (P=0.001), platelet (P=0.001), K time (P=0.02), and MA (P=0.05). There was no statistically significant difference in the rates of thrombosis, bleeding, blood loss, or the need for a PRBC transfusion between the 2 groups. There was a statistically significant correlation between aberrant R time (P=0.01) and abnormal alpha angle (P=0.01) in adults with cirrhosis compared to children with cirrhosis. When comparing children with and without cirrhosis at the time of LT, those with cirrhosis did have deficiencies in fibrinogen and platelets, but this was not reflected in a significantly increased risk of bleeding. However, clotting factor abnormalities were more common in adults with cirrhosis than in children.

Source: journals.lww.com/jpgn/Abstract/2022/10000/Characterization_of_Biomarkers_of_Hemostasis_and.24.aspx