The Particulars: Left ventricular end-diastolic pressure (LVEDP) is often measured during PCI. However, the correlation between LVEDP and systolic function has not been well defined.

Data Breakdown: A retrospective study analyzed data from patients with acute ST-segment elevation myocardial infarction (STEMI) who underwent PCI. Patients with an LVDEP greater than 25 mm Hg (Group A) were compared with others involved in the study (Group B). Patients in Group A had significantly lower average ejection fractions than those in Group B at admission and follow-up. Group A patients were also significantly more likely to have persistent systolic dysfunction, with an odds ratio of 14.8, when compared with Group B patients.

Take Home Pearl: Elevated LVDEP at the time of primary PCI appears to increase the risk for persistent systolic dysfunction in patients with STEMI.