Although clinical characteristics of eosinophilic esophagitis (EoE) are widely documented in the literature, characterization of abnormalities encountered by patients with other eosinophilic gastrointestinal disorders (EGIDs) is limited. Researchers intended to describe and contrast patient-reported gastrointestinal and extragastrointestinal symptoms and comorbidities in non-EoE EGIDs, including eosinophilic gastritis, gastroenteritis, and colitis, in comparison to EoE, using data from a patient contact registry. Chi-square and the Mann-Whitney U test were used to make statistical comparisons. The relationships between therapy and feelings of isolation were studied using multivariable analysis. A larger proportion of individuals with a non-EoE EGID reported more frequent specific and nonspecific gastrointestinal symptoms, such as nausea, stomach discomfort, diarrhea, constipation, and bloating, out of the 715 people who reported an EGID diagnosis. Non-EoE EGID participants were more likely to experience tiredness, isolation, and deep muscle or joint discomfort. For participants with EoE, specific dietary exclusion and elemental formula treatments were related with an increased likelihood of feeling alone on a regular basis.

There are significant variations in the symptoms and comorbidities experienced by people with EoE EGIDs vs those who do not have EoE EGIDs. More research is required to identify the elements that may contribute to the high illness burden of these poorly understood diseases.