Existing literature has suggested that these patients are at increased risk for recurrent disease. This study aims to identify CRS patients’ histopathologic features with tissue eosinophilia and compare tissue eosinophilia’s influence on the effects of age and revision surgery on histopathology.

The authors utilized a structured histopathology report to analyze removed sinus tissue during functional endoscopic sinus surgery. Researchers conducted a binomial logistic regression analysis to evaluate the association of age at diagnosis, tissue eosinophil count, and history of revision surgery with histopathology variables.

Researchers included two hundred and eighty-one CRS patients, of which one hundred and six had tissue eosinophilia. Regression analysis associated tissue eosinophilia with the degree of inflammation, neutrophilic infiltrate, basement membrane thickening, squamous metaplasia, fibrosis, and eosinophilic aggregates. Age and history of revision surgery on multivariate analysis were not significant predictors of histopathology variables.

The study concluded that the tissue eosinophilia appears to be the predominant driving factor of histopathologic changes irrespective of previous sinus surgery or age at diagnosis. These findings may have important implications for after surgery management and prognosis for patients with tissue eosinophilia presenting for revision surgery.

Reference: https://journals.sagepub.com/doi/full/10.1177/1945892419896239