In recent years, there has been an increase in the number of reports of food-dependent exercise-induced anaphylaxis (FDEIA). The purpose of this study is to explain the usual management of FDEIA, including provocation testing, and to identify concerns that remain unresolved. Aspirin provocation tests for FDEIA allow us to confirm the definitive diagnosis and make differential diagnoses. FDEIA symptoms can be produced by aspirin and the causative meal in rare situations without exercise. Exercise, like aspirin or alcohol, may only be a supplement to FDEIA.

The processes of FDEIA development are yet unknown. It has been proposed that exercise reduces the threshold of a food allergy in FDEIA. More study is needed to understand the mechanism of FDEIA and develop appropriate disease management techniques.