This cross-sectional survey has determined the vaccines’ hesitancy in Italy in connection with the human papillomavirus (HPV). Two thirds of the parents learnt of HPV contamination and knew it would be a precautionary measure. This was more likely to be the knowledge of parents who had vaccinated their child against HPV. The overwhelming majority regarded the vaccine as beneficial to deter cancers linked to HPV with an average of 8.4. This optimistic approach was greater among parents who recognised that the HPV infection was preventive and got advice from doctors who had vaccinated their children for HPV. They were worried they could get their infection with HPV, they wanted information on HPV vaccine, and were concerned that their children could contract HPV infection. The average Parent attitudes to children’s vaccines (PACV) scores of one third are uncertain about HPV vaccination with a ranking of about 50 percent.

Unmarried respondents were more likely to be reluctant when they did not learn about HPV infection and did not realise that the injection was a precautionary step, when they did not think that the vaccine was helpful in preventing HPV-related cancers and when they needed knowledge about HPV vaccination.