The purpose of this study is to see if heat shock protein 70 (Hsp70) gene polymorphisms are linked to SLE susceptibility, the efficacy of glucocorticoids (GCs) treatment, and improvements in health-related quality of life. A case-control study comprised 499 SLE patients and 499 controls, and a follow-up research included 468 SLE patients treated with GCs for 12 weeks. Using the SLE disease activity score, patients who completed the 12-week follow-up were classified into GCs-sensitive and GCs-insensitive groups. The SF-36 was used to assess SLE patients’ health-related quality of life, and genotyping was done using an enhanced multiplex ligation detection reaction. SLE susceptibility was linked to rs2075800. In the follow-up research, rs2075799 was linked to improved mental health, but we found no link between the effectiveness of GCs and Hsp70 gene polymorphisms.

Polymorphisms in the Hsp70 gene may be linked to susceptibility to SLE and improved mental health in the Chinese Han population.