The goal was to evaluate the immunological response to immunization in children and young persons who suffer from inflammatory bowel disease (IBD). In IBD patients, vaccination response might be affected by both the illness and its therapy. Relevant papers and statistical analysis have been sought in the Medical Databases. As a consequence, the study comprised 20 papers, 9 of which fulfilled the meta-analysis requirements. In healthy people and patients without immunosuppressive therapy the immune response was better, but was not statistically significant.

Vaccine immunogenicity in children and adolescents with IBD is not significantly lower than in healthy children and adolescents. Immune response to immunization is also not considerably lower in individuals on immunosuppressive treatment than in those who are not.