With the advent of microbiota as a possible driver for host inflammation, the significance of iIgA is becoming more and more essential. This review examines the current evidence on the consequences and the potential role of microbial dysbiosis in inflammatory patients of the clinical IgA deficiency in microbiota. In selective IgA deficiency and a common variable immune deficiency, intestinal microbiota has been examined, which reveals that IgA plays a key role in maintaining gut microbiota homeostasis, which affects the symbionts and pathobionts. While IgA deficit may be linked to microbial translocation and systemic inflammation, adequate IgG and IgM induction in the IgA deficit but not common variable immunodeficiency may partially compensate for this deficiency. Microbiota repair treatments rely mostly on faecal microbiota transplantations. Therapy techniques It is presently uncertain whether this can lower systemic PID inflammation.

Microbial dysbiosis and systemic inflammation are connected with clinical IgA deficiency. There is little evidence of microbiome targeting medicines in PID, however IgA based therapy may be useful and faecal microbiota transplantation in individuals with anticorps impairment is well tolerated.

Reference: https://journals.lww.com/co-allergy/Abstract/2019/12000/Immunoglobulin_A_and_microbiota_in_primary.4.aspx