The impact of convection volume (CV) on pre-dilution online haemodiafiltration (Pre-OL-HDF) in patients was studied.

For a study, researchers did a retrospective, cross-sectional investigation on 126 Pre-OL-HDF patients. Dialysis circumstances, laboratory data, and same-day post-dialysis body composition measures were evaluated using bioimpedance spectroscopy. According to their CV, patients were separated into two groups: ≥median value and <median value. Linear regression analyses were performed for the reduction ratios (RRs) of β2-microglobulin and α1-microglobulin, as well as body composition.

The research patients’ ages, dialysis vintages, and CVs were 64±12 years, 81 (48-154) months, and 43.2 (38.5-55.9) L/session, respectively. When compared to the lower CV (≥43 L/session) group (n = 60, P<.01), the higher CV (43 L/session) group (n = 66) had significantly higher RRs of β2-microglobulin and α1-microglobulin, lean tissue index, body cell mass index, total body water (TBW), extracellular water (ECW), and intracellular water (ICW). Serum albumin and fat tissue index did not differ substantially between groups. CV/ECW, CV/TBW, and CV/ICW, but not unadjusted CV, were significant predictors of β2- and α1-microglobulin RRs (P<.05). The lean tissue and body cell mass indices, but not the fat tissue index, were associated with CV and the RRs of β2- and α1-microglobulin (P< kb.05). 

Higher values in the lean tissue index and body cell mass index were detected in patients on Pre-OL-HDF with higher CV vs. lower CV, and CV adjusted to body water may be effective in prescribing tailored conditions for Pre-OL-HDF.