Researchers conducted this study to characterize the impact on kidney injury of RUTI in the frail elderly.

A prospective observational study in 200 frail elderly subjects for one year. Groups: GA: residents without RUTI, GB: subjects with RUTI. Variables: age, concomitant diseases, GFR, urine NGAL at the beginning (NGAL-1) and end (NGAL-2) of the study, urine N-acetyl glucosaminidase (NAG) at the beginning (NAG-1), and the last (NAG-2) of the study, urine TGFβ-1.

The mean age was 84.33 years old, with no difference between GA and GB. Mean NGAL-1 was 1.29 ng/ml. There was lower in GA than in GB. Mean NGAL-2 was 1.41 ng/ml. NGAL-2 was lower in GA than in GB. Mean NAG-1 was 0.38 UU.II/ml. NAG-2 was lower in GA compared with GB. Mean TGFβ-1 was 23.43 pg/ml. TGFβ-1 was lower in GA than GB. There were no differences in the presence of secondary diagnoses between GA and GB. NAG-2 and NGAL-1 were the most determining renal function factors; in GA, it was NGAL-2, followed by NAG-1; in GB, it was NGAL-1, followed by NAG-2.

Frail elderly with RUTI have higher urinary levels of renal injury markers, specifically NGAL, NAG, and TGFβ-1, chronically in periods between urinary tract infection (UTI).

Reference: https://journals.sagepub.com/doi/full/10.1177/1756287220974133