This season states that the Seasonal influenza is a common respiratory tract viral infection that might lead to localized outbreaks or even pandemic, having substantial impacts on human health as well as societies and economies. According to the World Health Organization (WHO), an estimated 290 000-650 000 deaths were associated with influenza globally in 2017.1, 2 In the United States, the estimated mean annual total cost of influenza reached $11.2 billion.3 Seasonal influenza imposed a significant economic burden to the healthcare system and society. While environmental factors are typically regarded as strong drivers of influenza epidemic, inconsistency in findings was evident in existing literature possibly due to variations in climatic conditions. Thus, there is a need to provide additional insights relevant to influenza seasonality. A reliable epidemic forecast is crucial to optimize vaccination strategy, strengthen healthcare resource preparedness, and ultimately ease the disease burden of influenza. Several studies have assessed the effects of weather on influenza activity. Tamerius et al4 explored the association between climate variability and timing of seasonal influenza epidemics in 78 study sites sampled globally.

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