For a study, it was determined that indoor allergen proteins cross-react in children with allergic respiratory disorders, according to in vitro investigations. However, just a few research had looked at in vivo responsiveness. A skin prick test (SPT) with commercial indoor solutions was commonly employed in clinical practice. Researchers wanted to see how well SPT agreement between pairs of common indoor allergens worked in children with allergic respiratory illness. They examined SPT values from children aged 2 to 18 who had been diagnosed with respiratory allergies. The researchers collected data on home dust mites (Dermatophagoides farinae, Dermatophagoides pteronyssinus), cockroaches (Periplaneta americana, Blatella germanica), cats, and dogs. Sensitization was determined as a wheel diameter of less than 3 mm. The Kappa coefficient (κ) was employed to assess sensitization concordance for each allergen pair.

The charts of 300 children were examined, with 187 (62.33 %) males. With 183 (61%), 140 (46.67%), 45 (15%), and 30 (10%) sensitizations to house dust mite (HDM), cockroach, cat, and dog, respectively, the mean age was (7.43±3.29) years. The cockroach and HDM had a moderate sensitivity concordance of (κ=0.53) (95 % CI: 0.42–0.64). There was moderate agreement between the dog and the cat: (κ=0.41) (95 % CI: 0.30–0.52). Both (cat=0.17 (95% CI: 0.09–0.24)) and (dog=0.09 (95 % CI: 0.03–0.14)) demonstrated poor concordance in HDM-sensitized children. (Cat=0.19 (95% CI; 0.11–0.28)) and (dog=0.11 (95% CI; 0.04–0.18)) were likewise shown to have poor concordance in cockroach-sensitized children. They found that the SPT responses of HDM and cockroaches and dogs and cats were moderately similar. These responses may be due to cross-reactivity. Researchers should investigate the component-resolved diagnosis in children who have co-sensitization to these allergen combinations.