Trivalent inactivated influenza vaccination (TIV) has been administered free of charge to primary, middle, and high school students in Beijing since 2007. During the 2016–2017 influenza season, researchers calculated influenza VE against laboratory-confirmed influenza disease among schoolchildren in Beijing, China. A case–control approach was used to examine the VE of 2016–2017 TIV against laboratory-confirmed influenza virus infection in school-age children. To estimate VE, matched cases–control sets were subjected to conditional logistic regression. The influence of previous immunisation on current VE was also investigated. With a positive result of 55.5 percent, all 176 samples tested positive for influenza A virus. The average coverage rate of TIV among students in the 37 schools in 2016–2017 was 30.6 percent. TIV had a fully adjusted VE of 69 percent against laboratory-confirmed influenza in 2016–2017: 60 percent for influenza A pdm09 and 73 percent for influenza A. (H3N2). The total VE for vaccines received just in 2015–2016, only in 2016–2017, and both seasons were 46 percent, 77 percent, and 57 percent, respectively.

During school outbreaks, we discovered that the VE of 2016–2017 TIV was moderate against influenza A(H3N2) and A(H1N1)pdm09 viruses.