This study was done to evaluate the international literature on the risk of perinatal death associated with IPI.
Two independent reviewers screened titles and abstracts identified in MEDLINE, EMBASE, and Scopus.
A narrative review was performed for all included studies that met the inclusion criteria of the study. Random-effects meta‐analysis was used to compare unadjusted odds of perinatal death associated with IPI <6 months and IPI ≥6 months. Analyses were then performed.
There was a total of 624 unique articles identified, 26 articles out of 624 met the inclusion criteria. The pooled unadjusted odds ratio of perinatal death for IPI <6 months was 1.34 following a previous live birth, 0.85 following a previous miscarriage, and 1.07 following a previous stillbirth compared with IPI ≥6 months. However, few high‐income country studies reported an association after adjustment. Fewer studies evaluated the impact of long IPI on perinatal death and what evidence was available showed mixed results.
The study concluded that a possible association between short IPI and the risk of perinatal death following a live birth, especially in countries other than the well-developed countries.