Laparoscopic total gastrectomy (LTG) is a routine treatment for gastric cancer, but its efficacy remains uncertain due to a lack of clinical evidence. This study aims to compare the safety of LG with conventional open total gastrectomy (OTG) in patients with clinical stage I gastric cancer.
This multicenter, prospective, noninferiority, randomized clinical trial included a total of 214 patients with clinical stage I gastric cancer who were analyzed for mortality and morbidity. The patients were randomly assigned in a 1:1 ratio to receive LTG (n=105) or OTG (n=109). The primary outcomes of the study were morbidity and mortality within 30 days following surgeries.
The findings suggested that the overall rates of mortality and morbidity were comparable in the two groups. Intraoperative complications were reported in 3 patients (2.)%) in the LTG group and 4 patients (3.7%) in the OTG group. Besides, no significant difference was observed in the overall postoperative complication rate, which was 18.1% in the TG group and 17.4% in the OTG group. One death was reported in the LTG group.
The research concluded that the safety profile of LTG was comparable to OTG in patients with clinical stage I gastric cancer.