Larger studies are needed focusing on genome-wide association studies (GWASs) of asthma and allergic diseases, especially in the patients with childhood-onset asthma and allergic diseases group, and in African American and Latino/Hispanic populations.
Recently a review was conducted assessing GWASs published between January 1, 2018, and June 30, 2019. There were 38 GWASs reported in 19 articles, during this time. The review indicated that childhood-onset asthma is associated with the most independent loci when compared other asthma and allergic disease groups. Researchers found that adult-onset asthma and moderate-to-severe asthma are associated with fewer genes. Asthma and allergic diseases have significant genetic overlap, in particular childhood-onset asthma, which involves genes that reflect the importance of barrier function biology, and to HLA region genes. Even though the largest GWASs of African American and Latino/Hispanic populations were published during this time the groups are still underrepresented in studies.
https://pubmed.ncbi.nlm.nih.gov/31677964/
