Metabolic liver disorders (MLDs) are a diverse category of hereditary illnesses for which liver transplantation can give final therapy. Due to the scarcity of dead donor organs, some people who may benefit from transplant are unable to do so. Living related liver transplantation (LrLT) utilising relatives as donors has emerged as one answer to this challenge. This method is well-established internationally, particularly in Asian nations, with reduced waiting times and patient and graft survival rates comparable to dead donor liver transplantation.

However, in many western nations live donors are underused, probably because of the worry of low effectiveness with heterozygous donors. Researchers examined available data, showing that for the majority of MLDs with excellent metabolism correction the use of heterozygous donors for liver transplantation is safe. The use of LrLT should be advocated for the treatment of MLDs in addition to the dead donor liver transplantation (DDLT).

Reference: https://journals.lww.com/jpgn/Abstract/2021/01000/Living_Related_Liver_Transplantation_for_Metabolic.5.aspx