Magnesium intoxication is a serious health concern. However, studies evaluating maternal-neonatal outcomes in magnesium (Mg)-intoxicated women with preeclampsia with severe features (PESF) treated with magnesium sulfate (MgSO4) were lacking. This study was done with the purpose to evaluate the maternal-neonatal outcome in magnesium (Mg)-intoxicated women with preeclampsia with severe features (PESF) treated with magnesium sulfate (MgSO4).

A total of 19 Mg intoxicated PESF women were selected as the sample for the study. They were then compared with 166 PESF women without signs of intoxication as the controls for the purpose of comparison.

Mg serum levels of cases were higher compared to the control group (12.36 ± 3.54 mg/dl versus 2.69 ± 0.83 mg/dl). 3 women died and 3 had major maternal morbidity in the cases group compared with zero in the control group. Mg intoxication was also significantly associated with perinatal deaths and low Apgar scores at 1 minute and at 5 minutes.

The findings of this study concluded that the Mg intoxication is associated with an increased risk of maternal and perinatal mortality and morbidity.

Reference: https://doi.org/10.1080/10641955.2020.1754851