Researchers set out to determine the global burden of acute respiratory syndrome and found that coronavirus 2, a newly described coronavirus that causes coronavirus disease (COVID-19), is a major cause of illness and death. Acute sickness often results in digestive and liver symptoms, which have been well discussed in the medical literature. Post-COVID-19 cholangiopathy is most commonly observed in adults. However, data pertaining to kids was scarce. Their mission was to create a portrait of a young survivor of COVID-19 who went on to develop liver damage. This study looked back at a series of cases to see how young individuals fared after experiencing hepatic symptoms after contracting COVID-19. We collected data on the patients’ demographics, medical background, symptoms, diagnostic procedures, imaging, histology, treatments, and final outcomes. Five teenagers who were infected with COVID-19 and recovered had liver damage, according to the study’s findings. Two distinct clinical manifestations were observed. Two otherwise healthy infants, aged 3 and 5 months, developed acute liver failure and needed transplants right away. Severe necrosis, cholangiogram growth, and lymphocyte infiltration were all present in their liver explant. About three children, two of whom were 8 years old and the other who was 13, presented to the hospital with hepatitis and cholestasis. Lymphocytic portal, parenchymal, and bile duct proliferation were found in biopsies of the livers of about 2 children. They started all three of them on steroid treatment, which was stopped when their liver enzymes normalised. There was no viral or metabolic cause that could be pinpointed after a comprehensive aetiology workup was performed on all 5 instances.

Source – journals.lww.com/jpgn/Abstract/2022/09000/Long_COVID_19_Liver_Manifestation_in_Children.5.aspx