For a study, it was determined that Infective endocarditis (IE) was a rare and serious infection that resulted difficulties during pregnancy. The National Readmissions Database was used to obtain information between October 2015 and October 2018. Demographic characteristics, comorbidities, and outcomes were compared between patients with maternity-associated and non-maternity-associated IE and obstetric patients who delivered with and without IE. Weighted regressions were used to analyze results in adjusted models. The study identified 12,602 reproductive-aged female patients with a diagnosis of IE, of which 382 (weighted national estimate, 748) were maternity-associated. Of these cases, 117 (weighted national estimate, 217) occurred during a delivery admission. Maternity-associated infection was found to be associated with younger age (mean, 29.0 vs 36.6 years; P<.001), Medicaid coverage (72.5% vs 47.2%; P<.001), and drug use (76.2% vs 59.8%; P<.001). Mortality was comparable (8.1% vs 10.6%; adjusted rate ratio [aRR], 1.03; 95% CI: .71–1.48). Patients who delivered without IE, IE complicating delivery was associated with worse maternal and fetal results, including maternal mortality (17.2% vs <0.01%; aRR, 323.32; 95% CI: 127.74–818.37) and preterm birth (55.7% vs 10.1%; aRR, 3.61; 95% CI, 2.58–5.08). Maternity-associated IE does not appear to confer additional risk for adverse outcomes over non-maternity-associated infection. Patients who were delivered with IE were found to suffer worse maternal and fetal results than those whose deliveries were not complicated by IE.