Recent advances in the mechanics of persistent cough will be reviewed in this article.
Although the frequency of cough is comparable over the world, the illnesses connected with cough vary significantly by area. This might be due to changes in food, environmental exposure, diagnostic evaluation, and labeling based on geography. Cough frequency and cough reflex sensitivity may be successfully quantified using a variety of validated questionnaires and objective methods. Eosinophilic bronchitis cough responds to corticosteroid and montelukast anti-inflammatory treatment. The lack of airway hyperresponsiveness might be attributed to the production of prostaglandin E2, a bronchoprotective mediator. Coughing caused by neutrophilic bronchitis is linked to rhinitis and gastroesophageal reflux illness. Laryngeal hypersensitivity (LHS) is a novel idea that explains cough causes, suggests possibly new pharmacotherapies that target brain circuits as well as temporary receptor channels, and indicates how behavioral treatments might be successful in refractory cough. The notion also explains symptoms in a number of similar disorders, including vocal cord dysfunction.
New insights into cough mechanics with an emphasis on LHS aid in explaining cough symptoms and the role of successful interventions such as speech pathology intervention and neuromodulators.
Reference:journals.lww.com/co-allergy/Abstract/2014/02000/Mechanisms_of_cough.11.aspx
