Medication adherence is critical to relieving symptoms and slowing the development of systemic lupus erythematosus (SLE). The goal of this study was to look at medication adherence rates and the variables that contribute to nonadherence in Chinese SLE patients. Between January 2017 and February 2018, The Second Affiliated Hospital of Nantong University performed a cross-sectional research. Patients with SLE completed the Rheumatology Compliance Questionnaire to measure adherence, the SLE Disease Activity Index (SLEDAI) to assess disease activity, and the Hospital Anxiety and Depression Scale to assess anxiety and depression. Data was analysed using analyses, independent samples t tests, and logistic regression models. This study comprised 144 SLE patients, and we discovered that 43.1 percent of them were noncompliant. Adherence in SLE patients was associated with education, SLEDAI, anxiety, and sadness. Furthermore, logistic regression models revealed education, SLEDAI, and depression as significant predictors of nonadherence.

The SLEDAI and Hospital Anxiety and Depression Scale were used for the first time to assess demographic, clinical, and psychological variables for drug adherence in Chinese SLE patients. The study found that 56.9% of SLE patients were not adhering to their medications, and that education, SLEDAI, and depression were all substantially associated with medication adherence in SLE. These findings showed that more attention should be paid to medication adherence in SLE patients, particularly those with a lower level of education, a higher SLEDAI score, and depression, in order to enhance SLE patients’ adherence and hence their quality of life.