A self-reported migraine history is associated with a higher risk for some adverse pregnancy outcomes, according to a research letter published in the American Journal of Obstetrics & Gynecology. Eliza C. Miller, MD, and colleagues assessed whether self-reported migraine among nulliparous individuals is associated with higher odds of adverse pregnancy outcomes. The analysis included 9,450 nulliparous US individuals with singleton gestation in early pregnancy followed through delivery. Among participants, 19.1% reported a diagnosis of migraine at the first visit. White race, recent smoking history, autoimmune disorders, and chronic kidney disease were more common among participants with migraine. In an adjusted analysis, participants with migraine had increased odds of any adverse pregnancy outcome (adjusted OR, 1.26), as well as any hypertensive disorder of pregnancy and both medically indicated and spontaneous preterm birth. A larger effect was seen in participants who reported recent medication use (adjusted OR, 1.49).
