Migraine is a neurovascular headache disorder. The consequential effects of migraine headaches are unclear, but few studies have linked migraine in pregnant women with an increased risk of maternal stroke. The objective of this study is to investigate the association between migraine and cardiovascular diseases (CVD) during pregnancy.

This is a US population-based case-control study that included a total of 18,345,538 pregnancy-related discharges. The primary outcome of the study is the diagnosis of migraine by ICD codes 346.0 and 346.1 and the incidence of stroke and other CVD diseases.

Out of the total participants, 33,956 migraine codes were discovered, with the prevalence being 185 per 100,000 deliveries. Cardiovascular diseases that were closely associated with migraine codes during pregnancy were stroke (OR 15.05), myocardial infarction (OR 2.11), pulmonary embolus/venous thromboembolism (3.23), and hypertension (8.61). Migraine, however, was not associated with non-vascular diagnoses, such as transfusions, postpartum infection, and pneumonia.

The research concluded that there was a strong association between active peripartum migraine and the diagnosis of cardiovascular diseases during pregnancy. However, the study doesn’t clarify whether migraine or cardiovascular condition occurred first. Therefore, more prospective studies of pregnant women are required to deduce the exact association between migraine and vascular diseases.

Ref: https://jamanetwork.com/journals/jamaneurology/article-abstract/2766569?resultClick=1