Various studies and experiments have been conducted so far in order to measure the effect of PKD1 in osteoblasts. The main actor of this research has been the mouse. It was observed that the mice in question were affected by various symptoms of the incidence and occurrence of Pkd1 in osteoblasts. This was compared with the phenotype of bones in the human being and similar results were out. It was observed that the people who have been suffering from the problem of mineral bone disease are affected by a problem of mineral metabolism in the body. These symptoms of mineral metabolism were discovered in around 900 patients who at the same point of time were already suffering from mineral bone disease. These people tend to have greater swelling around their ligaments due to which 50 percent of the people are affected with and hence, find difficulty in making movements easily. Their bones lose their efficiency and hence, are 20 percent more brittle and hence, the studies have reported that they are more likely to develop fractures. The incidence of fractures in such people is more by 57 percent. They have a very less bone volume around 0.47 percent and hence, are very much affected as compared to the healthy persons. They must be given a diet rich in calcium.

Ref art: https://www.kidney-international.org/article/S0085-2538(20)30958-3/fulltext